Chitosan for constructing stable polymer-inorganic suspensions and multifunctional membranes for wound healing. (1st June 2022)

• Record Type: Journal Article
• Authors: Wang, Liangyu; Du, Lin; Wang, Mengmeng; Wang, Xing; Tian, Saihua; Chen, Yan; Wang, Xiaoyue; Zhang, Jie; Nie, Jun; Ma, Guiping
• Is Part Of: Carbohydrate polymers. Volume 285(2022)
• Publication Date: 2022-06-01
• Subjects: Chitosan -- Sugar coating -- Molecular needles -- Humidity sensing -- Infectious wounds therapy; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2022.119209
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: Restricted by the rigid chain structure, chitosan-based materials are very fragile and easy to break up. Herein, a stable and positively charged chitosan/Ti3 C2 Tx suspension was successfully constructed by adjusting mixing sequence, pH and ratio of chitosan to Ti3 C2 Tx to prepare a multifunctional membrane (P-CM) with self-standing ability, good flexibility, biocompatibility, excellent photothermal antibacterial properties, and sensitive humidity sensing properties. In the first stage, protonated chitosan acted as sugar coatings was able to be encapsulated on the surface of Ti3 C2 Tx nanosheets by electrostatic self-assembly, in turn achieving charge reversal of the nanoparticles. In the second stage, chitosan acted as molecular needles to suture the membrane formed by chitosan/Ti3 C2 Tx particles via vacuum filtration (VAF) with the commercial flexible poly(vinylidene fluoride) (PVDF) membrane. The as-prepared P-CM membrane simultaneously solves the problem of insufficient flexibility of a single component chitosan membrane and the poor bonding between pure Ti3 C2 Tx membranes and substrate membrane. Graphical abstract: Unlabelled Image Highlights: Positive charged stable suspensions were constructed using chitosan as sugar coatings. Chitosan as molecular needles improved interfacial bonding. Multifunctional chitosan-based membranes with real time humidity sensing were prepared. Photothermal effect enhanced antibacterial activity of chitosan.