Chemoenzymatic one-pot reaction from carboxylic acid to nitrile via oxime. Issue 1 (7th December 2021)

• Record Type: Journal Article
• Authors: Horvat, Melissa; Weilch, Victoria; Rädisch, Robert; Hecko, Sebastian; Schiefer, Astrid; Rudroff, Florian; Wilding, Birgit; Klempier, Norbert; Pátek, Miroslav; Martínková, Ludmila; Winkler, Margit
• Is Part Of: Catalysis science & technology. Volume 12:Issue 1(2022)
• Page Start: 62
• Page End: 66
• Publication Date: 2021-12-07
• Subjects: Catalysis -- Periodicals; 541.395
• DOI: 10.1039/d1cy01694f
• Languages: English
• ISSNs: 2044-4753

Abstract

Abstract : We report a new chemoenzymatic cascade starting with aldehyde synthesis by carboxylic acid reductase (CAR) followed by chemical in situ oxime formation and enzymatic dehydration by aldoxime dehydratase (Oxd). Abstract : We report a new chemoenzymatic cascade starting with aldehyde synthesis by carboxylic acid reductase (CAR) followed by chemical in situ oxime formation. The final step to the nitrile is catalyzed by aldoxime dehydratase (Oxd). Full conversions of phenylacetic acid and hexanoic acid were achieved in a two-phase mode.