Pediatric angioedema: Essential features and preliminary results from the Hereditary Angioedema Global Registry in Italy. (3rd February 2020)

• Record Type: Journal Article
• Authors: Cancian, Mauro; Perego, Francesca; Senter, Riccardo; Arcoleo, Francesco; De Pasquale, Tiziana; Zoli, Alessandra; Cicardi, Marco; Zanichelli, Andrea
• Is Part Of: Pediatric allergy and immunology. Volume 31(2020)Supplement 24
• Page Start: 22
• Page End: 24
• Publication Date: 2020-02-03
• Subjects: C1‐inhibitor -- disease registry -- hereditary angioedema -- HGR -- ITACA -- pediatric; Allergy in children -- Periodicals; Immunologic diseases in children -- Periodicals; 617
• DOI: 10.1111/pai.13170
• Languages: English
• ISSNs: 0905-6157

Abstract

Abstract: Isolated angioedema, which is a localized, non‐pitting, and transient swelling of the subcutaneous or submucosal tissue not associated with pruritus, urticaria, or anaphylaxis, may be classified, based on genetic pattern and mediators, respectively, as acquired or hereditary and histamine‐ or non‐histamine‐induced. The pediatric population with C1‐INH‐HAE (Hereditary angioedema due to C1‐inhibitor deficiency) is mostly symptomatic. The frequency of symptoms in such a population compared to adults seems to be lower, but we need more prospective data to conclude on this point. The HGR (Hereditary angioedema global registry), which collects symptoms in real time, will probably provide such information. In terms of treatments, pediatric patients are significantly disadvantaged due to the few studies aimed at registering treatment for this population.