Antibacterial and antiviral high-performance nanosystems to mitigate new SARS-CoV-2 variants of concern. (March 2022)

• Record Type: Journal Article
• Authors: Tiwari, Shivani; Juneja, Subhavna; Ghosal, Anujit; Bandara, Nandika; Khan, Raju; Wallen, Scott L.; Ramakrishna, Seeram; Kaushik, Ajeet
• Is Part Of: Current opinion in biomedical engineering. Volume 21(2022)
• Publication Date: 2022-03
• Subjects: NS Nanosystem -- SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 -- COVID-19 Coronavirus diseases 2019 -- FDA Food and Drug Administration -- FET Field-effect-transistor -- LBL Layer-by-Layer; Multifunctional nanosystem -- Trapping and mitigation of COVID-19 -- Intelligent nano-healthcare -- Effective management of virus; Biomedical engineering -- Periodicals; 610.28
• DOI: 10.1016/j.cobme.2021.100363
• Languages: English
• ISSNs: 2468-4511

Abstract

Abstract: The increased severity of the COVID-19 infection due to new SARS-CoV-2 variants has resonated pandemic impact which made health experts to re-evaluate the effectiveness of pandemic management strategies. This becomes critical owing to the infection in large population and shortcomings in the existing global healthcare system worldwide. The designing of high-performance nanosystems (NS) with tunable performances seems to be the most efficient method to tackle infectious SARS-CoV-2 variants including recently emerged omicron mutation. In this direction, experts projects the versatile functionalized NS and their capabilities to mitigate SARS-CoV-2 propagation pathways by sensitization, antipathogenicity, photocatalysis, photothermal effects, immune response, developing efficient diagnostics assays or associated, selective biomarkers detection, and targeted drug delivery systems. To achieve these tasks, this opinion article project the importance of the fabrication of nano-enabled protective gear, masks, gloves, sheets, filtration units, nano-emulsified disinfectants, antiviral/bacterial paints, and therangostics to facilitate quarantine strategies via protection, detection, and treatment needed to manage COVID-19 pandemic in personalized manners. These functional protective high-performance antibacterial and antiviral NS can efficiently tackle the SARS-CoV-2 variants transmission through respiratory fluids and pollutants within water droplets, aerosols, air, and particulates along with their severe infection via neutralizing or eradicating the virus. Graphical abstract: Image 1 Highlights: Nanosystems for efficient sensing, treatment, and inhibition are required to manage COVID-19 pandemic. Antiviral and antibacterial nanosystems are developed to trap and neutralize SARS-CoV-2. These systems can be efficient barriers to manage human-to-human transmission of SARS-CoV-2. Airborne and particulate transmissions are manageable using nanotechnology. Delivery of COVID-19 vaccines to the targeted sites is achieved by using smart nano-carriers as drug transporters.