Pickering emulsions stabilized by biodegradable dextran-based nanoparticles featuring enzyme responsiveness and co-encapsulation of actives. (15th May 2022)

• Record Type: Journal Article
• Authors: Maingret, Valentin; Chartier, Coraline; Six, Jean-Luc; Schmitt, Véronique; Héroguez, Valérie
• Is Part Of: Carbohydrate polymers. Volume 284(2022)
• Publication Date: 2022-05-15
• Subjects: Biodegradation -- Stimuli-responsiveness -- Encapsulation -- Sustainable release -- Dextranase -- Fluorescence; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2022.119146
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: In this study, Pickering emulsions of dodecane and medium chain triglyceride (MCT) oils were stabilized by simply alkylated-dextran nanoparticles. Our findings show that very little of these bio-friendly nanoparticles is necessary to stabilize Pickering emulsions while providing a high time stability (more than a year at 37 °C). As dextran is known to be cleavable by dextranase enzyme, hydrolysis of the nanoparticles in the presence of dextranase could be achieved. This allowed performing on-demand destabilization of Pickering emulsions. Furthermore, two different fluorescent probes were loaded into the stabilizing particles and the oil droplets respectively, providing a proof of concept for co-encapsulation of actives in advanced delivery applications. Additionally, to a conventional fluorescence probe, quinine, an antimalarial drug was also encapsulated into the nanoparticles. Graphical abstract: Unlabelled Image