Machine learning for atherosclerotic tissue component classification in combined near-infrared spectroscopy intravascular ultrasound imaging: Validation against histology. (March 2022)

• Record Type: Journal Article
• Authors: Bajaj, Retesh; Eggermont, Jeroen; Grainger, Stephanie J.; Räber, Lorenz; Parasa, Ramya; Khan, Ameer Hamid A.; Costa, Christos; Erdogan, Emrah; Hendricks, Michael J.; Chandrasekharan, Karthik H.; Andiapen, Mervyn; Serruys, Patrick W.; Torii, Ryo; Mathur, Anthony; Baumbach, Andreas; Dijkstra, Jouke; Bourantas, Christos V.
• Is Part Of: Atherosclerosis. Volume 345(2022)
• Page Start: 15
• Page End: 25
• Publication Date: 2022-03
• Subjects: Intravascular ultrasound -- Near-infrared spectroscopy -- Plaque characterization -- Machine learning; Arteriosclerosis -- Periodicals; Electronic journals; 616.136
• DOI: 10.1016/j.atherosclerosis.2022.01.021
• Languages: English
• ISSNs: 0021-9150

Abstract

Abstract: Background and aims: Accurate classification of plaque composition is essential for treatment planning. Intravascular ultrasound (IVUS) has limited efficacy in assessing tissue types, while near-infrared spectroscopy (NIRS) provides complementary information to IVUS but lacks depth information. The aim of this study is to train and assess the efficacy of a machine learning classifier for plaque component classification that relies on IVUS echogenicity and NIRS-signal, using histology as reference standard. Methods: Matched NIRS-IVUS and histology images from 15 cadaveric human coronary arteries were analyzed (10 vessels were used for training and 5 for testing). Fibrous/pathological intimal thickening (F-PIT), early necrotic core (ENC), late necrotic core (LNC), and calcific tissue regions-of-interest were detected on histology and superimposed onto IVUS frames. The pixel intensities of these tissue types from the training set were used to train a J48 classifier for plaque characterization (ECHO-classification). To aid differentiation of F-PIT from necrotic cores, the NIRS-signal was used to classify non-calcific pixels outside yellow-spot regions as F-PIT (ECHO-NIRS classification). The performance of ECHO and ECHO-NIRS classifications were validated against histology. Results: 262 matched frames were included in the analysis (162 constituted the training set and 100 the test set). The pixel intensities of F-PIT and ENC were similar and thus these two tissues could not be differentiated by echogenicity. With ENC and LNC as a single class, ECHO-classification showed good agreement with histology for detecting calcific and F-PIT tissues but had poor efficacy for necrotic cores (recall 0.59 and precision 0.29). Similar results were found when F-PIT and ENC were treated as a single class (recall and precision for LNC 0.78 and 0.33, respectively). ECHO-NIRS classification improved necrotic core and LNC detection, resulting in an increase of the overall accuracy of both models, from 81.4% to 91.8%, and from 87.9% to 94.7%, respectively. Comparable performance of the two models was seen in the test set where the overall accuracy of ECHO-NIRS classification was 95.0% and 95.5%, respectively. Conclusions: The combination of echogenicity with NIRS-signal appears capable of overcoming limitations of echogenicity, enabling more accurate characterization of plaque components. Graphical abstract: Image 1 Highlights: IVUS grey-scale pixel intensity analysis has limited accuracy in assessing plaque composition. NIRS-signal was combined with a machine learning classifier trained to distinguish tissue types using IVUS pixel intensities. The combined approach improved plaque characterization accuracy and was superior to stand-alone IVUS. This approach may be advantageous for vulnerable plaque detection and for monitoring plaque evolution.