Growth from birth to 6 months of infants with and without intrauterine preeclampsia exposure. (12th April 2022)

• Record Type: Journal Article
• Authors: Gow, Megan L.; Roberts, Lynne; Henry, Amanda; Davis, Gregory; Mangos, George; Pettit, Franziska; Khouri, Joseph M.; Dosen, Ana; Brown, Mark A.; Craig, Maria E.
• Is Part Of: Journal of developmental origins of health and disease. Volume 13:Number 2(2022)
• Page Start: 151
• Page End: 155
• Publication Date: 2022-04-12
• Subjects: Growth -- infants -- preeclampsia -- small for gestational age; Developmental biology -- Periodicals; Embryology, Human -- Periodicals; Disease susceptibility -- Periodicals; Prenatal influences -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; 612.64
• DOI: 10.1017/S2040174421000167
• Languages: English
• ISSNs: 2040-1744

Abstract

Abstract: Intrauterine preeclampsia exposure affects the lifelong cardiometabolic health of the child. Our study aimed to compare the growth (from birth to 6 months) of infants exposed to either a normotensive pregnancy or preeclampsia and explore the influence of being born small for gestational age (SGA). Participants were children of women participating in the Post-partum, Physiology, Psychology and Paediatric follow-up cohort study. Birth and 6-month weight and length z-scores were calculated for term and preterm (<37 weeks) babies, and change in weight z-score, rapid weight gain (≥0.67 increase in weight z-score) and conditional weight gain z-score were calculated. Compared with normotensive exposed infants ( n = 298), preeclampsia exposed infants ( n = 84) were more likely to be born SGA (7% versus 23%; P < 0.001), but weight gain from birth to 6 months, by any measure, did not differ between groups. Infants born SGA, irrespective of pregnancy exposure, were more likely to have rapid weight gain and had greater increases in weight z-score compared with those not born SGA. Preeclampsia exposed infants born SGA may benefit from interventions designed to prevent future cardiometabolic disease.