Tools to implement the World Health Organization End TB Strategy: Addressing common challenges in high and low endemic countries. (March 2020)

• Record Type: Journal Article
• Authors: Al Abri, Seif; Kasaeva, Thereza; Migliori, Giovanni Battista; Goletti, Delia; Zenner, Dominik; Denholm, Justin; Al Maani, Amal; Cirillo, Daniela Maria; Schön, Thomas; Lillebæk, Troels; Al-Jardani, Amina; Go, Un-Yeong; Dias, Hannah Monica; Tiberi, Simon; Al Yaquobi, Fatma; Khamis, Faryal Ali; Kurup, Padmamohan; Wilson, Michael; Memish, Ziad; Al Maqbali, Ali; Akhtar, Muhammad; Wejse, Christian; Petersen, Eskild
• Is Part Of: International journal of infectious diseases. Volume 92 Supplement(2020)
• Page Start: S60
• Page End: S68
• Publication Date: 2020-03
• Subjects: Tuberculosis -- Control -- Prevention -- Latent TB infection -- Care -- Screening -- Migrants; Communicable diseases -- Periodicals; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; Electronic journals; 616.9
• DOI: 10.1016/j.ijid.2020.02.042
• Languages: English
• ISSNs: 1201-9712

Abstract

Highlights: Latent tuberculosis (TB) is an important reservoir for developing active TB. Screening, for instance with an interferon-gamma release assay, will identify the majority of people with latent TB. Molecular epidemiology is key to understand transmission dynamics between nationals and migrants. The development of public–private partnerships is needed to mobilize the resources needed to achieve the End TB goal. Abstract: Aim: The purpose of this viewpoint is to summarize the advantages and constraints of the tools and strategies available for reducing the annual incidence of tuberculosis (TB) by implementing the World Health Organization (WHO) End TB Strategy and the linked WHO TB Elimination Framework, with special reference to Oman. Methods: The case-study was built based on the presentations and discussions at an international workshop on TB elimination in low incidence countries organized by the Ministry of Health, Oman, which took place from September 5 to September 7, 2019, and supported by the WHO and European Society of Clinical Microbiology and Infectious Diseases (ESCMID). Results: Existing tools were reviewed, including the screening of migrants for latent TB infection (LTBI) with interferon-gamma release assays, clinical examination for active pulmonary TB (APTB) including chest X-rays, organization of laboratory services, and the existing centres for mandatory health examination of pre-arrival or arriving migrants, including examination for APTB. The need for public–private partnerships to handle the burden of screening arriving migrants for active TB was discussed at length and different models for financing were reviewed. Conclusions: In a country with a high proportion of migrants from high endemic countries, screening for LTBI is of high priority. Molecular typing and the development of public–private partnerships are needed.