Status and perspective of lab-on-a-chip systems for common diseases: a systematic review from 2003 to 2013. (January 2016)

• Record Type: Journal Article
• Authors: Gebauer, Alexander; Schmidt, Silke; Hoffmann, Wolfgang
• Is Part Of: Personalized medicine. Volume 13:Number 1(2016)
• Page Start: 71
• Page End: 91
• Publication Date: 2016-01
• Subjects: cardiovascular diseases -- cancer -- diagnosis -- HIV -- influenza -- lab-on-a-chip -- systematic review -- tuberculosis; Pharmacogenomics -- Periodicals; Pharmacogenetics -- Periodicals; 615.19
• DOI: 10.2217/pme.15.42
• Languages: English
• ISSNs: 1741-0541

Abstract

Background: Lab-on-a-chip systems (LOCs) are a useful aid for the individualization of therapeutic algorithms at the point-of-care.Materials & methods: We performed a systematic literature review on LOCs for diseases with a global impact for healthcare.Results: A total of 1007 articles matched the previously specified search criteria, thereof 65 studies could be included in this review. A total of 55 different LOCs were evaluated, most for diagnosis or monitoring of cancer (n = 24). For other diseases we found considerably less analyzed LOCs. The analytical performance of the LOCs was usually very good, 37 (67%) LOCs had a sensitivity higher than 90%.Conclusion: Although LOC systems performance has been positively evaluated in the great majority of studies, the testing was mostly limited to the research laboratory setting rather than real-world scenarios.