A simple risk score for detecting radiological occult metastasis in patients with resectable or borderline resectable pancreatic ductal adenocarcinoma. (24th August 2021)

• Record Type: Journal Article
• Authors: Sakaguchi, Tatsuma; Satoi, Sohei; Hashimoto, Daisuke; Yamamoto, Tomohisa; Yamaki, So; Hirooka, Satoshi; Ishida, Mitsuaki; Ikeura, Tsukasa; Inoue, Kentaro; Sekimoto, Mitsugu
• Is Part Of: Journal of hepato-biliary-pancreatic sciences. Volume 29:Number 2(2022)
• Page Start: 262
• Page End: 270
• Publication Date: 2021-08-24
• Subjects: occult distant metastasis -- resectable or borderline resectable pancreatic ductal adenocarcinoma -- risk score -- staging laparoscopy; Liver -- Diseases -- Periodicals; Biliary tract -- Diseases -- Periodicals; Pancreas -- Diseases -- Periodicals; 617.556
• DOI: 10.1002/jhbp.1026
• Languages: English
• ISSNs: 1868-6974

Abstract

Abstract: Background: We advocated carbohydrate antigen (CA) 19‐9 ≥ 150 U/mL and tumor size ≥30 mm as "high‐risk markers" for predicting unresectability among patients with radiologically resectable (R) or borderline resectable (BR) pancreatic ductal adenocarcinoma (PDAC). The main aim is to establish a risk scoring system for occult abdominal metastasis (OAM) in R/BR PDAC. Methods: Predictors of OAM were investigated retrospectively in an experiment cohort from 2006 to 2018. The proposed risk scoring system was validated in another cohort from 2019 to 2020. Results: Five hundred and thirteen eligible patients were divided into the experimental (405 patients; OAM, 22%) and validation cohorts (108 patients). Multivariate analysis identified tumor location of body/tail (odds ratio [OR] 4.45, P < .0001) and "high‐risk markers" (OR 2.07, P = .011) as independent predictors of OAM. A scoring system consisting of body/tail (yes: 1, no: 0) and "high‐risk markers" (yes: 1, no: 0) was constructed. In the validation cohort, when staging laparoscopy (SL) was performed for patients with scores 1/2, the eligibility for SL, sensitivity, and negative predictive value of OAM were 55%, 91%, and 96%, respectively. Conclusions: Tumor location of body/tail and "high‐risk markers" were independent predictors of OAM, composing our simple and reproducible risk scoring system. Abstract : Highlight Sakaguchi and colleagues investigated the predictors for occult abdominal metastasis of resectable or borderline resectable pancreatic ductal adenocarcinoma. Tumor location in the pancreatic body or tail, carbohydrate antigen 19‐9 ≥ 150 U/mL, and tumor size ≥30 mm constitute a simple and reproducible risk scoring system of occult abdominal metastasis.