HVAD versus heartmate III bridge to heart transplantation: Waitlist and posttransplant outcomes. Issue 3 (20th December 2021)

• Record Type: Journal Article
• Authors: Hess, Nicholas R.; Witer, Lucas; Katz, Marc R.; Pope, Nicolas H.; Tedford, Ryan J.; Houston, Brian A.; Kilic, Arman
• Is Part Of: Clinical transplantation. Volume 36:Issue 3(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-12-20
• Subjects: heart transplantation, HeartWare -- HVAD: Heartmate III, left ventricular assist device; Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ctr.14546
• Languages: English
• ISSNs: 0902-0063

Abstract

Abstract: Background: This study compared outcomes of patients bridged with either the Heartware HVAD or Heartmate 3 (HM3) device to orthotopic heart transplantation (OHT). Methods: The United Network of Organ Sharing registry was queried to perform two separate analyses of adult, isolated OHT candidates bridged with HVAD or HM3. First, waitlist outcomes were compared among patients waitlisted 1/1/2015‐3/20/2020. Second, posttransplant survival was compared among those transplanted 1/1/2015‐3/20/2020. Results: Two thousand two hundred fifty‐five candidates were waitlisted within the study period, 1587 (70.4%) bridged with HVAD and 668 (29.6%) with HM3. At 1 year from waitlisting, cumulative incidence of OHT higher in the HVAD cohort ( p < .001). During the same time period, 2643 patients underwent OHT, 2154 (81.5%) with prior HVAD and 489 (18.5%) with HM3. Yearly proportions of patients bridged with HM3 increased across the study period and decreased for HVAD ( p < .001). HM3‐bridged recipients had shorter waitlist times, longer graft cold ischemic times, and experienced a higher rate of posttransplant dialysis requirement. Unadjusted and risk‐adjusted posttransplant mortality rates were similar between both groups. Conclusions: Posttransplant survival is equivalent regardless of device type used for bridging. However, HM3 patients had lower likelihood of reaching transplantation, which may be a reflection of the recent heart allocation policy changes.