Primary angiosarcoma of the seminal vesicle. (15th November 2021)

• Record Type: Journal Article
• Authors: Singla, Vrinda; Goyal, Shikha; Periasamy, Kannan; Sali, Akash Pramod; Madan, Renu; Khosla, Divya; Kapoor, Rakesh
• Is Part Of: Andrologia. Volume 54:Number 3(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-11-15
• Subjects: angiosarcoma -- immunohistochemistry -- metronomic chemotherapy -- seminal vesicle -- volumetric modulated arc therapy; Andrology -- Periodicals; Infertility, Male -- Periodicals; 616.69
• DOI: 10.1111/and.14311
• Languages: English
• ISSNs: 0303-4569

Abstract

Abstract: Angiosarcomas are rare but highly aggressive malignancies originating from lymphatic or vascular endothelial cells and may arise from any site in the body. Angiosarcomas of the genitourinary tract, especially of seminal vesicle origin, are extremely rare with only five reported cases. Surgery forms the mainstay of therapy in localised disease while adjuvant therapies are still being refined. We present the case of a 40‐year old gentleman who presented with lower urinary tract symptoms and, on evaluation, was found to have a localised angiosarcoma originating in right seminal vesicle and offered laparoscopic resection, adjuvant paclitaxel (12 weekly cycles) and adjuvant radiation therapy (66 gray in 30 fractions). He developed a peritoneal nodular recurrence after 6 months of radiotherapy that was successfully salvaged with excision and metronomic chemotherapy, which he is currently receiving. Localised angiosarcomas need multimodality management despite small size. Attempts should be made for surgical salvage of limited recurrences whenever feasible.