Nasopharyngeal cancer: Incidence and prognosis of human papillomavirus and Epstein–Barr virus association at a single North American institution. Issue 4 (18th January 2022)

• Record Type: Journal Article
• Authors: Wu, Shannon S.; Chen, Bonnie; Fleming, Christopher W.; Shah, Akeesha A.; Griffith, Christopher C.; Domb, Chaim; Reddy, Chandana A.; Campbell, Shauna R.; Woody, Neil M.; Lamarre, Eric D.; Lorenz, Robert R.; Prendes, Brandon L.; Scharpf, Joseph; Schwartzman, Larissa; Geiger, Jessica L.; Koyfman, Shlomo A.; Ku, Jamie A.
• Is Part Of: Head & neck. Volume 44:Issue 4(2022)
• Page Start: 851
• Page End: 861
• Publication Date: 2022-01-18
• Subjects: Epstein–Barr virus -- human papillomavirus -- nasopharyngeal cancer -- nasopharynx -- survival outcomes; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.26976
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: The prognostication of Epstein–Barr virus (EBV) and human papillomavirus (HPV) status in nasopharyngeal cancer (NPC) is unclear. Methods: This retrospective study analyzed NPC from 2000 to 2019. Results: Seventy‐eight patients were included: 43 EBV +, 12 HPV +, 23 EBV − /HPV −, and 0 EBV + /HPV + . All p16 + tumors were also positive for HPV‐CISH. Baseline characteristics were not different between groups except age, N‐classification, and Karnofsky Performance Scale (KPS) ( p < 0.05). For EBV +, HPV +, and EBV − /HPV − respectively, 3‐year overall survival (OS) was 89.9%, 69.8%, and 52.5% ( p = 0.006). EBV − /HPV − status was significantly associated with worse OS but not freedom from progression (FFP) on univariate analysis, and did not remain a significant predictor of OS after adjusting for KPS, age, and group stage. Conclusions: EBV + NPC tumors were seen in younger, healthier patients than HPV + and EBV − tumors, and there were no cases of coinfection. The association of viral status with OS was insignificant after adjusting for KPS and age.