Effectiveness of contact investigations for tuberculosis control in Arkansas. (7th September 2015)

• Record Type: Journal Article
• Authors: Guzzetta, Giorgio; Ajelli, Marco; Yang, Zhenhua; Mukasa, Leonard N.; Patil, Naveen; Bates, Joseph H.; Kirschner, Denise E.; Merler, Stefano
• Is Part Of: Journal of theoretical biology. Volume 380(2015)
• Page Start: 238
• Page End: 246
• Publication Date: 2015-09-07
• Subjects: Mathematical model -- Contact tracing -- Process assessment (Health Care); Biology -- Periodicals; Biological Science Disciplines -- Periodicals; Biology -- Periodicals; Biologie -- Périodiques; Theoretische biologie; Biology; Periodicals; 571.05
• DOI: 10.1016/j.jtbi.2015.05.031
• Languages: English
• ISSNs: 0022-5193

Abstract

Abstract: Comprehensive assessment of the effectiveness of contact investigations for tuberculosis (TB) control is still lacking. In this study, we use a computational model, calibrated against notification data from Arkansas during the period 2001–2011, that reproduces independent data on key features of TB transmission and epidemiology. The model estimates that the Arkansas contact investigations program has avoided 18.6% (12.1–25.9%) of TB cases and 23.7% (16.4–30.6%) of TB deaths that would have occurred during 2001–2014 if passive diagnosis alone were implemented. If contacts of sputum smear-negative cases had not been included in the program, the percentage reduction would have been remarkably lower. In addition, we predict that achieving national targets for performance indicators of contact investigation programs has strong potential to further reduce TB transmission and burden. However, contact investigations are expected to have limited effectiveness on avoiding reactivation cases of latent infections over the next 60 years. Highlights: We evaluate the effectiveness of TB contact investigations in Arkansas in 2001–2014. We estimate that contact investigations have avoided about 20% of TB cases and deaths. Treatment of latent TB infections contributed marginally (2–3%) to this purpose. We show the importance of tracing contacts of sputum smear-negative index patients. Achieving national performance targets can significantly improve TB control.