P670 Familial Inflammatory Bowel Disease is associated with a more adverse disease compared to sporadic cases. (21st January 2022)

• Record Type: Journal Article
• Authors: Boaz, E; Ariella, B G S; Menachem, S; Eran, G; Petachia, R; Shlomo, Y; Koslowsky, B
• Is Part Of: Journal of Crohn's and colitis. Volume 16(2022)Supplement 1
• Page Start: i578
• Page End: i578
• Publication Date: 2022-01-21
• Subjects: Inflammatory bowel diseases -- Periodicals; 616.344005
• DOI: 10.1093/ecco-jcc/jjab232.791
• Languages: English
• ISSNs: 1873-9946

Abstract

Abstract: Background: A family history increases the risk for inflammatory bowel diseases (IBD). However, data on differences in phenotypic characteristics and severity among patients with a strong family history of IBD are both scarce and controversial. The aim of the present study was to compare the phenotypic features of IBD patients with 4 or more affected first-degree relatives with sporadic cases of IBD. Methods: Patients with familial and sporadic IBD were identified from the institutional IBD database. IBD Patients with at least 4 first-degree affected relatives were selected for analysis and were compared to non-matched sporadic cases with IBD chosen randomly from our local database. The sporadic cases had a first and second degree negative family history of IBD. Comparison for type of IBD [Crohn's disease (CD) vs. ulcerative colitis (UC)], age at onset as well as for disease extent, behavior, perianal disease, extraintestinal manifestations (EIM), and indicators of severe disease (i.e., need for biological agents and surgery) were analyzed. Results: Thirty six patients with familial IBD (29 Crohn's disease (CD), 7 ulcerative colitis (UC)) were compared to 88 sporadic IBD patients (61 CD, 24 UC, 3 IBD-unclassified). Disease duration was 10.1 ± 8.3 in the familial and 8.1 ± 7.3 years in the sporadic cases, p=0.18. The familial cases were younger at diagnosis (19.1± 8.6 vs. 25.7 ± 11.8, P < 0.003). Patients with familial compared to sporadic IBD were significantly more likely to require steroid treatment (84.8% vs. 54.5%, P < 0.002) biological treatment (91.6%, vs. 63.6%, P < 0.002) or surgery (25%, vs. 11.4%, P = 0.056), respectively. Conclusion: IBD with a very strong positive family history is associated with younger age at onset and a more adverse IBD phenotype compared to sporadic IBD.