Case‐based survey: The impact of breast‐cancer treatment on fertility in Japan. Issue 3 (21st December 2021)

• Record Type: Journal Article
• Authors: Yamazaki, Rena; Ono, Masanori; Sugie, Tomoharu; Inokuchi, Masafumi; Ishikawa, Satoko; Horage, Yuki; Kojima, Yasuyuki; Iwasa, Takeshi; Hara, Tetsuaki; Nagata, Yumi; Kato, Keiichi; Michikura, Yasuhito; Kuramoto, Takeshi; Uchida, Soko; Horie, Akihito; Fujiwara, Hiroshi; Matsuzaki, Toshiya
• Is Part Of: Journal of obstetrics and gynaecology research. Volume 48:Issue 3(2022)
• Page Start: 553
• Page End: 562
• Publication Date: 2021-12-21
• Subjects: breast neoplasms -- cancer survivors -- fertility -- reproduction -- surveys and questionnaires; Gynecology -- Periodicals; Obstetrics -- Periodicals; 618.1005
• DOI: 10.1111/jog.15132
• Languages: English
• ISSNs: 1341-8076

Abstract

Abstract: Aim: To assess the impact of breast‐cancer treatment on fertility. Methods: We conducted a retrospective, case‐based survey of treatments administered for infertility and pregnancy outcomes after patients underwent treatment for breast cancer. Surveys were distributed to breast oncology facilities and reproductive endocrinology and infertility (REI) facilities. Results: As high as 60% of the pregnancies in women under the age of 35 years occurred spontaneously. Additionally, the fertility rates decreased as age increased (under 35 years of age: 40%, 35–39 years of age: 21%, 40–44 years of age: 10%, respectively). In women who became pregnant after treatment for breast cancer, conception was achieved within 1 to 3 years after beginning to try for pregnancy. Conclusions: After treatment for breast cancer, women can expect spontaneous pregnancy, especially if they are under 35 years of age. It is important for patients 35 years of age and older to commence assisted reproductive technology in a timely manner when pursuing fertility after treatment for breast cancer.