Prevalence of primary aldosteronism in type 2 diabetes mellitus and hypertension: A prospective study from Western India. (27th September 2021)

• Record Type: Journal Article
• Authors: Memon, Saba S.; Lila, Anurag; Barnabas, Rohit; Goroshi, Manjunath; Sarathi, Vijaya; Shivane, Vyankatesh; Patil, Virendra; Shah, Nalini; Bandgar, Tushar
• Is Part Of: Clinical endocrinology. Volume 96:Number 4(2022)
• Page Start: 539
• Page End: 548
• Publication Date: 2021-09-27
• Subjects: aldosterone -- Asian Indians -- hyperaldosteronism -- hypertension -- prevalence -- screening -- type 2 diabetes mellitus; Endocrinology -- Periodicals; 616.4005
• DOI: 10.1111/cen.14598
• Languages: English
• ISSNs: 0300-0664

Abstract

Abstract: Objective: Type 2 diabetes mellitus (T2DM) and hypertension commonly coexist; however, underlying primary aldosteronism (PA) can lead to worsening of hypertension, glycemia and cardiovascular risk. We aim to screen patients with T2DM and hypertension for PA by conducting a prospective monocentric study from Western India, which included adults with T2DM and hypertension from the outpatient diabetes clinic. Design: Prospective study. Patients and Measurements: Patients with an aldosterone renin ratio of ≥1.6 ng/dl/µIU/ml with plasma aldosterone concentration (PAC) ≥ 10 ng/dl were considered to be positive on a screening test. A PAC ≥ 6 ng/dl on seated saline suppression test (SST) was used to confirm the diagnosis of PA. Results: Four hundred and eighty‐six patients were included in this study. Seventy‐six (15.6%, 95% confidence interval [CI]: 12.7%–19.1%) patients had a positive screening test with positive confirmatory test in 20 of the 36 (55.5%, 95% CI: 39.3%–71.7%) screen‐positive patients who underwent SST. Patients with positive screening test had a higher proportion of females (65.8% vs. 50%; p = .011), frequent history of hypertensive crises (21.1% vs. 8%; p = .001), uncontrolled blood pressure (51.3% vs. 34.6%; p = .006), diagnosis of hypertension before diabetes (32.9% vs. 21.7%; p = .035) and higher systolic (137.6 ± 6.9 vs. 131.2 ± 17.8 mmHg; p = .004) and diastolic (85.3 ± 11.1 vs. 81.7 ± 10.7 mmHg; p = .007) blood pressures. Patients with positive confirmatory test had longer duration of diabetes (108 [60–162] vs. 42 [24–87] months; p = .012), hypertension (84 [42–153] vs. 36 [15–81] months; p = .038) and higher creatinine (1.16 [1.02–1.42] vs. 0.95 [0.84–1.12] mg/dl; p = .021). Conclusions: PA is prevalent (at least 4.1%) in Asian Indian patients with T2DM and hypertension. Further studies are needed to assess the cost‐effectiveness of routine screening.