A new homoisoflavan from Dracaena cinnabari Balf. f. resin: α-glucosidase and COX-II inhibitory activity. Issue 5 (4th March 2022)

• Record Type: Journal Article
• Authors: Helal, Iman E.; Elsbaey, Marwa; Zaghloul, Ahmed M.; Mansour, El-Sayed S.
• Is Part Of: Natural product research. Volume 36:Issue 5(2022)
• Page Start: 1224
• Page End: 1229
• Publication Date: 2022-03-04
• Subjects: Dragon's blood -- Dracaena cinnabari Balf. f. -- homoisoflavan -- α-glucosidase -- COX-II; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1869229
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new homoisoflavan, identified as (3 R )-7-hydroxy-3′, 4′-methylenedioxyhomoisoflavan, was isolated from Dracaena cinnabari Balf. f. resin. The structure was elucidated by one- and two-dimensional NMR spectroscopy as well as high resolution mass spectrometry. In addition, a diverse group of flavonoids were isolated, representing homoisoflavans, flavans, flavanones, chalcones and dihydrochalcones. The compounds were evaluated for their α-glucosidase and COX-II inhibition activity. The obtained IC50 values of the tested flavonoids gave an insight about some key structural features to their α-glucosidase and COX-II inhibitory activity. For α-glucosidase inhibitory activity, a flavanone skeleton was favorable over a flavan. For COX-II inhibition, the introduction of a fused heterocyclic ring at the homoisoflavan skeleton enhanced the activity. Abstract : UF0001