Four new resorcinol derivatives with neuroprotective activities from Xylaria nigripes. Issue 6 (19th March 2022)

• Record Type: Journal Article
• Authors: Li, Lan-Qing; Li, Jing; Long, Hong-Ping; Liu, Ji-Kai; Wang, Xian
• Is Part Of: Natural product research. Volume 36:Issue 6(2022)
• Page Start: 1522
• Page End: 1528
• Publication Date: 2022-03-19
• Subjects: Xylaria nigripes -- resorcinol -- neuroprotective effects; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1897591
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Four new resorcinol derivatives, namely (−)/(+)-xylarinig A (1 ), as well as xylarinigs B (2 ) and C (3 ), were isolated from the ethyl acetate extracts of the solid fermentation of Xylaria nigripes . Their structures were established by comprehensive spectroscopic analysis combined with electronic circular dichroism (ECD) calculations. Compound 1 is an optical mixture, and was resoluted into optical pure enatiomers (+)-1 and (−)-1 by chiral HPLC. The neuroprotective effects of 1 –3 against the damage of PC12 cells induced by oxygen and glucose deprivation (OGD) were evaluated. Graphical Abstract: