A new dibenzofuran derivative from the stem bark of Scyphocephalium ochocoa with anti-inflammatory and cytotoxic activities. Issue 6 (19th March 2022)

• Record Type: Journal Article
• Authors: Feuya Tchouya, Guy Raymond; Foundikou, Hibrahim; Mbiantcha, Marius; Kezetas, Jean Jules Bankeu; Bongui, Jean-Bernard; Tchouankeu, Jean Claude; Lebibi, Jacques; Dethe, Dattatraya H.
• Is Part Of: Natural product research. Volume 36:Issue 6(2022)
• Page Start: 1503
• Page End: 1514
• Publication Date: 2022-03-19
• Subjects: Scyphocephalium ochocoa -- scyphocephalione A -- dibenzofuran -- anti-inflammatory activity -- cytotoxic activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1894561
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The phytochemical investigation of the dichloromethane/methanol (1:1) extract of the stem bark of Scyphocephalium ochocoa, led to the isolation of one new dibenzofuran derivative, named scyphocephalione A (1 ), along with three other compounds, including epicatechin (2 ), gentisic acid (3 ) and myo-inositol (4 ). The structures of all the compounds were established with help of spectroscopic data including IR, UV, MS, 1 D- and 2 D-NMR, as well as by comparison with previously reported data in literature, and chemical modification. All the compounds were obtained from the genus Scyphocephalium for the first time. The anti-inflammatory activity (using chemiluminescence technique) of the crude extract and compound 1, together with NO inhibition (using ELISA), TNF-α (using ELISA) and MCF-7 cells cytotoxicity effects (using MTT assay) of compound 1 were assessed. From the results obtained, compound 1 could be considered as a promising chemotherapeutic agent for the treatment of inflammatory diseases. GRAPHICAL ABSTRACT: