N-Difluoromethylation of N-pyridyl-substituted anilines with ethyl bromodifluoroacetate. Issue 9 (16th February 2022)

• Record Type: Journal Article
• Authors: Duan, Jindian; Choy, Pui Ying; Gan, Kin Boon; Kwong, Fuk Yee
• Is Part Of: Organic & biomolecular chemistry. Volume 20:Issue 9(2022)
• Page Start: 1883
• Page End: 1887
• Publication Date: 2022-02-16
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d2ob00119e
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A general protocol for N -difluoromethylation of aniline derivatives is developed. Abstract : A general protocol for N -difluoromethylation of aniline derivatives is developed. Commercially available ethyl bromodifluoroacetate serves as a difluorocarbene source in the presence of a base. This carbene surrogate is attractive owing to its favorable stability, environmental friendliness and inexpensiveness. This reaction system features notable operational simplicity (bench top-grade solvents can be used without any pre-drying and do not require inert atmosphere protection). A wide range of functional groups in aniline derivatives are well-tolerated, and good-to-excellent product yields are generally obtained.