Self-catalyzed tumor ferroptosis based on ferrocene conjugated reactive oxygen species generation and a responsive polymer. Issue 20 (17th February 2022)

• Record Type: Journal Article
• Authors: Li, Jisi; Zong, Qingyu; Liu, Ye; Xiao, Xuan; Zhou, Jielian; Zhao, Zhongyi; Yuan, Youyong
• Is Part Of: Chemical communications. Volume 58:Issue 20(2022)
• Page Start: 3294
• Page End: 3297
• Publication Date: 2022-02-17
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc06742g
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : In this work, PTAF functions as a ferroptosis self-catalyst, through synergistic actions of self-catalyzed ˙OH accumulation and GPX4 indirect inactivation based on the ROS self-catalytic loop, effectively induced tumor ferroptosis. Abstract : In this work, we developed a ferroptosis self-catalyst, PTAF, exhibiting self-catalyzed ferroptosis for enhanced cancer therapy. Briefly, synergistic actions of self-catalyzed ˙OH accumulation and GPX4 indirect inactivation based on the establishment of the ROS self-catalytic loop effectively induced tumor ferroptosis, which provided a novel approach for enhanced tumor therapy.