CuCl2·2H2O/TBHP mediated synthesis of β-enaminones via coupling reaction of vinyl azides with aldehydes. Issue 9 (16th February 2022)

• Record Type: Journal Article
• Authors: Zhang, Yaohong; Luo, Mengqiang; Zhang, Yichan; Cheng, Kai; Li, Yong; Qi, Chenze; Shen, Runpu; Wang, Hai
• Is Part Of: Organic & biomolecular chemistry. Volume 20:Issue 9(2022)
• Page Start: 1952
• Page End: 1957
• Publication Date: 2022-02-16
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d1ob02479e
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A facile and efficient oxidative functionalization of vinyl azides with aldehydes furnishing a diverse array of β-acylated enaminones was developed. Abstract : A facile and efficient oxidative functionalization of vinyl azides with aldehydes furnishing a diverse array of β-acylated enaminones was developed. The cross coupling was accomplished in the presence of CuCl2 ·2H2 O/TBHP and produced the desired β-acylated enaminones in a ( Z )-stereo-selective and atom-economic manner, which make this protocol particularly attractive. In the transformation, the new C–C and C–N bonds were formed via a one-pot strategy including the process of radical addition and recombination.