A glycol nanomedicine via a metal-coordination supramolecular self-assembly strategy for drug release monitoring and chemo-chemodynamic therapy. Issue 20 (21st February 2022)

• Record Type: Journal Article
• Authors: Li, Jiahui; Wang, Yi; Pei, Zhichao; Pei, Yuxin
• Is Part Of: Chemical communications. Volume 58:Issue 20(2022)
• Page Start: 3338
• Page End: 3341
• Publication Date: 2022-02-21
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc00159d
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : We report a glycol nanomedicine based on a metal-coordination supramolecular self-assembly strategy for targeting drug delivery and release monitoring, as well as synergistic chemo-chemodynamic therapy. Abstract : A glycol nanomedicine based on a metal-coordination supramolecular self-assembly strategy of GluCC (a copper complex of glucose modified coumarin derivative) and a chemotherapeutic agent of doxorubicin (DOX) was successfully developed. In vitro studies revealed that the nanomedicine achieved drug target delivery and release monitoring. The anti-cancer efficiency could be enhanced through synergistic therapy of chemotherapy (CT) and chemodynamic therapy (CDT). It may gain important applications in drug tracking and CDT-combined cancer therapy.