Assembling anisotropic colloids using curvature-mediated lipid sorting. Issue 9 (24th January 2022)

• Record Type: Journal Article
• Authors: Kumar, Manoj; Singh, Anupam; Del Secco, Benedetta; Baranov, Maksim V.; van den Bogaart, Geert; Sacanna, Stefano; Thutupalli, Shashi
• Is Part Of: Soft matter. Volume 18:Issue 9(2022)
• Page Start: 1757
• Page End: 1766
• Publication Date: 2022-01-24
• Subjects: Soft condensed matter -- Periodicals; 530.413
• DOI: 10.1039/d1sm01517f
• Languages: English
• ISSNs: 1744-683X

Abstract

Abstract : Anisotropic colloidal geometry is used to drive lipid sorting in multi-component membranes along the colloids, which are then exploited to create "shape-anisotropic patchy colloids" for directed self-assembly. Abstract : The use of colloid supported lipid bilayers (CSLBs) for assembling colloidal structures has been of recent interest. Here, we use multi-component lipid bilayer membranes formed around anisotropic colloids and show that the curvature anisotropy of the colloids drives a sorting of the lipids in the membrane along the colloids. We then exploit this curvature-sensitive lipid sorting to create "shape-anisotropic patchy colloids" – specifically, we use colloids with six rods sticking out of a central cubic core, "hexapods", for this purpose and demonstrate that membrane patches self-assemble at the tip of each of the six colloidal rods. The membrane patches are rendered sticky using biotinylated lipids in complement with a biotin-binding streptavidin protein. Finally, using these "shape-anisotropic patchy colloids", we demonstrate the directed assembly of colloidal links, paving the way for the creation of heterogeneous and flexible colloidal structures.