NUIG4: A biocompatible pcu metal–organic framework with an exceptional doxorubicin encapsulation capacity. Issue 9 (26th January 2022)

• Record Type: Journal Article
• Authors: Ahmed, Ahmed; Efthymiou, Constantinos G.; Sanii, Rana; Patyk-Kazmierczak, Ewa; Alsharabasy, Amir M.; Winterlich, Meghan; Kumar, Naveen; Sensharma, Debobroto; Tong, Wenming; Guerin, Sarah; Farras, Pau; Hudson, Sarah; Thompson, Damien; Zaworotko, Michael J.; Tasiopoulos, Anastasios J.; Papatriantafyllopoulou, Constantina
• Is Part Of: Journal of materials chemistry. Volume 10:Issue 9(2022)
• Page Start: 1378
• Page End: 1385
• Publication Date: 2022-01-26
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d1tb02176a
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : The synthesis and characterization of the biocompatible MOF NUIG4 is reported; NUIG4 possesses an unprecedently high doxorubicin (DOX) encapsulation capacity (1955 mg DOX/g NUIG4 ) with a pH-controlled release mechanism. Abstract : Metal–organic frameworks (MOFs) are promising multifunctional porous materials for biomedical and environmental applications. Here, we report synthesis and characterization of a new MOF based on the tetrahedral secondary building unit [Zn4 O(CBAB)3 ] n (NUIG4 ), where CBABH2 = 4-((4-carboxybenzylidene)amino)benzoic acid. NUIG4 belongs to the family of MOFs with primitive cubic pcu topology, being a rare example with 4-fold interpenetration. The pore architecture enables unprecedentedly high doxorubicin (DOX) loading capacity (1955 mg DOX/g NUIG4) with pH-controlled release. Solid-state NMR and ab initio modeling confirmed formation of aromatic π–π stacking interactions between DOX and the framework. Preliminary cell-line experiments suggested a protective effect of NUIG4 on healthy HDF cells against DOX toxicity. NUIG4 also displays potential for adsorptive small-molecule gas separation, with a BET surface area of 1358 m 2 g −1 and high selectivity of 2.75 for C2 H2 over CO2 .