A critical review for advances on industrialization of immobilized cell Bioreactors: Economic evaluation on cellulose hydrolysis for PHB production. (April 2022)

• Record Type: Journal Article
• Authors: Boura, Konstantina; Dima, Agapi; Nigam, Poonam S.; Panagopoulos, Vassilios; Kanellaki, Maria; Koutinas, Athanasios
• Is Part Of: Bioresource technology. Volume 349(2022)
• Publication Date: 2022-04
• Subjects: Biocatalysts -- Bioreactors -- Industrialization -- Immobilized-Cell-Bioreactors -- Polyhydroxybutyrate; Biomass -- Periodicals; Biomass energy -- Periodicals; Bioremediation -- Periodicals; Agricultural wastes -- Periodicals; Factory and trade waste -- Periodicals; Organic wastes -- Periodicals; Bioénergie -- Périodiques; Déchets agricoles -- Périodiques; Déchets industriels -- Périodiques; Déchets organiques -- Périodiques; Déchets (Combustible) -- Périodiques; 662.88
• DOI: 10.1016/j.biortech.2022.126757
• Languages: English
• ISSNs: 0960-8524

Abstract

Highlights: A complete collection of papers for ICBs and immobilized cells. Advances on cell immobilization and ICBs. New concepts for research on ICBs and cell immobilization are proposed. Combination of bio-processing advances to achieve industrialization of ICBs. Techno-economic study on cellulose hydrolysis using ICB for PHB production. Abstract: Advances such as cell-on-cell immobilization, multi-stage fixed bed tower (MFBT) bioreactor, promotional effect on fermentation, extremely low temperature fermentation, freeze dried immobilized cells in two-layer fermentation, non-engineered cell factories, and those of recent papers are demonstrated. Studies for possible industrialization of ICB, considering production capacity, low temperatures fermentations, added value products and bulk chemical production are studied. Immobilized cell bioreactors (ICB) using cellulose nano-biotechnology and engineered cells are reported. The development of a novel ICB with recent advances on high added value products and conceptual research areas for industrialization of ICB is proposed. The isolation of engineered flocculant cells leads to a single tank ICB. The concept of cell factories without GMO is a new research area. The conceptual development of multi-stage fixed bed tower membrane (MFBTM) ICB is discussed. Finally, feasible process design and technoeconomic analysis of cellulose hydrolysis using ICB are studied for polyhydroxybutyrate (PHB) production.