Towards principled design of cancer nanomedicine to accelerate clinical translation. (January 2022)

• Record Type: Journal Article
• Authors: Souri, Mohammad; Soltani, M.; Moradi Kashkooli, Farshad; Kiani Shahvandi, Mohammad; Chiani, Mohsen; Shariati, Fatemeh Sadat; Mehrabi, Mohammad Reza; Munn, Lance L.
• Is Part Of: Materials today bio. Volume 13(2022)
• Publication Date: 2022-01
• Subjects: Tumor microenvironment -- Nanomedicine -- Drug delivery -- Nanoparticle design -- Drug loading -- Clinical translation; EPR Permeability and retention -- MDR Multidrug resistance -- TME Tumor microenvironment -- IFP Interstitial fluid pressure -- ECM Extracellular matrix -- TAF Tumor-associated fibroblast -- TAM Tumor-associated macrophage -- MPS Mononuclear phagocyte system -- RBC Red blood cell -- CFL Cell-free layer -- MMPs Matrix metalloproteinases -- TIMPs Tissue inhibitor of metalloproteinases -- DPD Dissipative particle dynamic -- CGMD Coarse-grained molecular dynamic -- MD Molecular dynamic -- MTA Multi-tadpole assemblies -- MEC Minimum effective concentration -- MTC Minimum toxic concentration; Materials science -- Periodicals; Biomedical engineering -- Periodicals; Biomedical materials -- Periodicals; 620.1
• DOI: 10.1016/j.mtbio.2022.100208
• Languages: English
• ISSNs: 2590-0064

Abstract

Abstract: Nanotechnology in medical applications, especially in oncology as drug delivery systems, has recently shown promising results. However, although these advances have been promising in the pre-clinical stages, the clinical translation of this technology is challenging. To create drug delivery systems with increased treatment efficacy for clinical translation, the physicochemical characteristics of nanoparticles such as size, shape, elasticity (flexibility/rigidity), surface chemistry, and surface charge can be specified to optimize efficiency for a given application. Consequently, interdisciplinary researchers have focused on producing biocompatible materials, production technologies, or new formulations for efficient loading, and high stability. The effects of design parameters can be studied in vitro, in vivo, or using computational models, with the goal of understanding how they affect nanoparticle biophysics and their interactions with cells. The present review summarizes the advances and technologies in the production and design of cancer nanomedicines to achieve clinical translation and commercialization. We also highlight existing challenges and opportunities in the field. Graphical abstract: Image 1