Computerized correction of blood base excess to full hemoglobin-O2 saturation. (April 2022)

• Record Type: Journal Article
• Authors: Giovannini, Ivo; Chiarla, Carlo
• Is Part Of: Computer methods and programs in biomedicine. Volume 216(2022)
• Publication Date: 2022-04
• Subjects: Acid-base balance -- Blood base excess -- Correction factor -- Critical illness -- O2-linked H+ exchange -- Haldane effect; Medicine -- Computer programs -- Periodicals; Biology -- Computer programs -- Periodicals; Computers -- Periodicals; Medicine -- Periodicals; Médecine -- Logiciels -- Périodiques; Biologie -- Logiciels -- Périodiques; Biology -- Computer programs; Medicine -- Computer programs; Periodicals; Electronic journals; 610.28
• DOI: 10.1016/j.cmpb.2022.106661
• Languages: English
• ISSNs: 0169-2607

Abstract

Abstract: Background and objective: A mathematical procedure was developed to obtain an accurate coefficient (-∆BEB ) for the correction of blood base excess to full hemoglobin-O2 saturation taking into account actual 2, 3-diphosphoglycerate (2, 3-DPG) concentration. Methods: Previously published laboratory data were carefully processed through regression analysis, by correlating laboratory measurements of -∆BEB with the corresponding values of plasma pH, CO2 tension and 2, 3-DPG. Results: Data processing allowed the development of two accurate fits to the original laboratory results for blood with normal 2, 3-DPG and for blood depleted of 2, 3-DPG (r 2 = 0.990 and 0.986, respectively, p < 0.0001 for both), as the main components of a procedure for estimating the correction factor in normal conditions and in moderate-to-extreme illness with extreme acid-base abnormalities. Conclusions: This regression-derived procedure can easily integrate any computer system to automatically obtain an accurate correction factor on the basis of plasma pH, CO2 tension, and 2, 3-DPG concentration if available. It may also allow for the assessment of small stoichiometric quantities involved in O2 -linked H + exchange and equilibrium (Haldane effect) in computer programs dedicated to these types of investigations.