A one-dimensional collagen-based biomechanical model of passive soft tissue with viscoelasticity and failure. (21st January 2021)

• Record Type: Journal Article
• Authors: Barrett, Jeff M.; Callaghan, Jack P.
• Is Part Of: Journal of theoretical biology. Volume 509(2021)
• Publication Date: 2021-01-21
• Subjects: Collagen -- Biomechanical modelling -- Failure -- Viscoelasticity; Biology -- Periodicals; Biological Science Disciplines -- Periodicals; Biology -- Periodicals; Biologie -- Périodiques; Theoretische biologie; Biology; Periodicals; 571.05
• DOI: 10.1016/j.jtbi.2020.110488
• Languages: English
• ISSNs: 0022-5193

Abstract

Highlights: We derived a set of ODEs which describe the constitutive behaviour of soft tissues. This model captures failure, creep, stress-relaxation, and hysteresis. We simulated a chronic injury scenario, arising from creep until rupture. Abstract: Introduction: Strains and sprains of soft tissues, including tendons and ligaments, are frequently occurring injuries. Musculoskeletal models show great promise in prediction and prevention of these injuries. However, these models rarely account for the viscoelastic properties of ligaments and tendons, much less their failure properties. The purpose of this project was to develop, simplify, and analyze a collagen-distribution model to address these limitations. Model development: A distribution-moment approximation was applied to an existing partial differential equation model to reduce its computational complexity. The resulting model was equipped with a Voigt model in series, which endowed it with viscoelastic properties in addition to failure properties. Results: The model was able to reproduce the characteristic toe, linear, and failure regions ubiquitous throughout in-vitro tests on tissue specimens. In addition, it was able to reproduce a tri-phasic creep test consisting of an initial deformation, a steady-state, and failure. Stress-relaxation and hysteresis were also reproducible by the model. Discussion and conclusion: The ability to reproduce so many characteristics of biological tissues suggests more bio-fidelity was achieved by the reduced model was other currently available models. Future work to further improve its bio-fidelity is proposed for specific tendons and ligaments.