The adaptive aging brain. (February 2022)

• Record Type: Journal Article
• Authors: Aron, Liviu; Zullo, Joseph; Yankner, Bruce A.
• Is Part Of: Current opinion in neurobiology. Volume 72(2022)
• Page Start: 91
• Page End: 100
• Publication Date: 2022-02
• Subjects: Neurobiology -- Periodicals; 573.8
• DOI: 10.1016/j.conb.2021.09.009
• Languages: English
• ISSNs: 0959-4388

Abstract

Abstract: The aging brain is shaped by many structural and functional alterations. Recent cross-disciplinary efforts have uncovered powerful and integrated adaptive mechanisms that promote brain health and prevent functional decline during aging. Here, we review some of the most robust adaptive mechanisms and how they can be engaged to protect, and restore the aging brain. Highlights: Adaptive mechanisms during aging maintain neural function. Age-related adaptations in metabolism, neural networks, and neuron–glia interactions promote stress resistance. Many aspects of human neural aging may be modifiable. The brain is a central regulator of systemic aging and lifespan.