Emerging role and promise of nanomaterials in organoid research. Issue 3 (March 2022)

• Record Type: Journal Article
• Authors: Mahapatra, Chinmaya; Lee, Ruda; Paul, Manash K.
• Is Part Of: Drug discovery today. Volume 27:Issue 3(2022)
• Page Start: 890
• Page End: 899
• Publication Date: 2022-03
• Subjects: NMs Nanomaterials -- iPSCs Induced pluripotent stem cells -- ESCs Embryonic stem cells -- aECM Artificial extracellular matrices -- GAG Glycosaminoglycans -- MDCK Madin–Darby Canine Kidney -- PDMS Polydimethylsiloxane -- PEG Polyethylene glycol -- PGA Poly(glycerol adipate) -- SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 -- PVs Polymeric vesicles -- GIT Gastrointestinal tract -- PLGA Poly(lactic‐co‐glycolic acid -- IBD Inflammatory bowel disease -- PDAC Pancreatic ductal adenocarcinoma -- PDTO Patient-derived tumor organoid -- IGO Intraductally grafted organoid -- LGR5 Leucine-rich repeat-containing G-protein-coupled receptor 5 -- HA Hyaluronic acid -- RGD Arginylglycylaspartic acid -- TNF-α Tumor necrosis factor -- CNS Central nervous system -- BBB Blood–brain barrier -- GelMA Gelatin methacryloyl -- TVOC Tumor-vasculature-on-a-chip; Organoids -- Nanomaterial -- Nanoparticle -- Organoid–nanoparticle interaction -- Matrix -- Drug screening -- Therapeutics; Drugs -- Design -- Periodicals; Drugs -- Research -- Periodicals; 615.1
• DOI: 10.1016/j.drudis.2021.11.007
• Languages: English
• ISSNs: 1359-6446

Abstract

Highlights: Application of nanomaterials in organoid systems. Nanoparticle interaction with organoids from different tissue sources. Engineering organoid microenvironmental using artificial extracellular matrices. Advances and future directions of nanomaterial-organoid interaction. Abstract: Organoids are 3D stem cell-derived self-organization of cells. Organoid bioengineering helps recreate and tailor their architecture in vitro to generate mini organ-like properties, providing the opportunity to study fundamental cell behavior in heterogeneous populations and as a tool to model various diseases. Nanomaterials (NMs) are becoming indispensable in regenerative medicine and in developing treatment modalities for various diseases. Therefore, organoid–NM interactions are set to gain traction for the development of advanced diagnostics and therapeutics. Here, we discuss the interactions of NMs with distinctive organoid types, organoid matrices, trafficking and cargo delivery, organs-on-a-chip, bioprinting, downstream therapeutic implications, and future approaches.