IgG4-related mastitis requiring differentiation from breast cancer: a case report. Issue 11 (29th November 2021)

• Record Type: Journal Article
• Authors: Asano, Yuka; Kashiwagi, Shinichiro; Kawano, Yuko; Tanaka, Sayaka; Kuwae, Yuko; Takashima, Tsutomu; Ohsawa, Masahiko; Hirakawa, Kosei; Ohira, Masaichi
• Is Part Of: Journal of surgical case reports. Volume 2021:Issue 11(2021)
• Publication Date: 2021-11-29
• Subjects: Surgery -- Periodicals; Surgery -- Case studies -- Periodicals; 617.005
• DOI: 10.1093/jscr/rjaa240
• Languages: English
• ISSNs: 2042-8812

Abstract

Abstract: Immunoglobulin (Ig) G4-related disease (IgG4-RD) is a group of chronic relapsing inflammatory conditions. Although IgG4-RD can occur in various organs, it is rarely observed in mammary glands. Here, we report a case of IgG4-related mastitis (IgG4-RM) that needed to be differentiated from breast cancer. A 54-year-old woman was examined for a tumor in her left breast. Mammary ultrasonography revealed an irregular hypoechoic tumor measuring 45.0 × 43.0 × 32.0 mm in size. A core-needle biopsy of the left breast tissue revealed a high degree of mixed T and B lymphocytic and plasma cell infiltration, as well as interstitial fibrosis. IgG4-RD was diagnosed based on hematological examination that revealed an abnormal IgG4 value of 332 mg/dl. All the clinical diagnostic criteria for IgG4 were met, resulting in a definitive diagnosis of IgG4-RM.