Bacteria–bacteriophage cycles facilitate Cholera outbreak cycles: an indirect Susceptible-Infected-Recovered-Bacteria- Phage (iSIRBP) model-based mathematical study. Issue 1 (31st December 2022)

• Record Type: Journal Article
• Authors: Habees, Asma Al; Aldabbas, Eman; Bragazzi, Nicola L.; Kong, Jude D.
• Is Part Of: Journal of biological dynamics. Volume 16:Issue 1(2022)
• Page Start: 29
• Page End: 43
• Publication Date: 2022-12-31
• Subjects: Cholera -- bacteriophage -- phage -- basic reproduction number; Biology -- Mathematical models -- Periodicals; 570.15118
• DOI: 10.1080/17513758.2021.2017032
• Languages: English
• ISSNs: 1751-3758

Abstract

Abstract : Cholera is an acute enteric infectious disease caused by the Gram-negative bacterium Vibrio cholerae . Despite a huge body of research, the precise nature of its transmission dynamics has yet to be fully elucidated. Mathematical models can be useful to better understand how an infectious agent can spread and be properly controlled. We develop a compartmental model describing a human population, a bacterial population as well as a phage population. We show that there might be eight equilibrium points, one of which is a disease free equilibrium point. We carry out numerical simulations and sensitivity analyses and we show that the presence of phage can reduce the number of infectious individuals. Moreover, we discuss the main implications in terms of public health management and control strategies.