Temporal trends in respiratory care and bronchopulmonary dysplasia in very preterm infants over a 10-year period in Spain. Issue 2 (28th July 2021)

• Record Type: Journal Article
• Authors: Avila-Alvarez, Alejandro; Zozaya, Carlos; Pértega-Diaz, Sonia; Sanchez-Luna, Manuel; Iriondo-Sanz, Martin; Elorza, Maria Dolores; García-Muñoz Rodrigo, Fermín
• Other Names: author non-byline.; Ginovart Gemma author non-byline.; Aloy Josep Figueras author non-byline.; Legorburu Alberto Pérez author non-byline.; Olmos Ramon Aguilera author non-byline.; López Eduardo Narbona author non-byline.; Terroba Sandra author non-byline.; Sanchez-Tamayo Tomás author non-byline.; Fernandez Dolores Elorza author non-byline.; Sánchez Araceli Corredera author non-byline.; Colomer Belén Fernández author non-byline.; Fernandez Ma Angeles Martinez author non-byline.; Terán De las Cuevas author non-byline.; Altuna Miguel Cortajarena author non-byline.; Díaz Carmen Macias author non-byline.; Jorge Pedro Fuster author non-byline.; Gracia Segundo Rite author non-byline.; Faci Purificación Ventura author non-byline.; Macián Isabel Izquierdo author non-byline.; Escobar-Izquierdo Ana Belén author non-byline.; Pico Luz Couce author non-byline.; Gutierrez-González Elena Pilar author non-byline.; Blanco Bravo D author non-byline.; Prado Yolanda Ruiz del author non-byline.; Martí Lourdes Urquía author non-byline.; Mozo Rafael Garcia author non-byline.; Caballero Pilar Jaraba author non-byline.; Martínez Cristina de Frutos author non-byline.; Martínez-Nadal Sílvia author non-byline.; Iriondo Martin author non-byline.; Serna Amaya Rodriguez author non-byline.; Santacruz María Gonzalez author non-byline.; Moreno-Galdo Maria Fernanda author non-byline.; Barnusell Joan Badia author non-byline.; Vicente Mar Montejo author non-byline.; Albújar Aintzane Euba; Mar author non-byline.; Perez Irene Cuadrado author non-byline.; Gutierrez Andres Martinez author non-byline.; Galiana Gemma Ginovart author non-byline.; Cuesta Jesús López author non-byline.; Muñoz José Santos author non-byline.; Albo María Suárez author non-byline.; Marugán-Isabel Víctor Manuel author non-byline.; Ramos María Victoria author non-byline.; Modamio Gerardo Romera author non-byline.; Vizcaíno Carolina author non-byline.; Navarro David Mora author non-byline.; Gordillo Laura Acosta author non-byline.; Mir Eduard Soler author non-byline.; Asensio Mercedes Granero author non-byline.; Capell Javier Estañ author non-byline.; García-Cabezas Miguel Angel author non-byline.; López Gómez D author non-byline.; Fagundo Alberto Trujillo author non-byline.; Sanz Israel Anquela author non-byline.; Arenas Antonio Segado author non-byline.; Pallás-Alonso Carmen Rosa author non-byline.; Romero Sabina author non-byline.; Armengod Carmen González author non-byline.; Lloreda-García Jose María author non-byline.; Comeche Laura Domingo author non-byline.; Vilella Laura Castells author non-byline.; Orayen Concepción Goñi author non-byline.; Sebastian Dolores Muro author non-byline.; Diaz Mara Fernandez author non-byline.; Victori Elena García author non-byline.;
• Is Part Of: Archives of disease in childhood. Volume 107:Issue 2(2022)
• Page Start: 143
• Page End: 149
• Publication Date: 2021-07-28
• Subjects: intensive care units -- neonatal -- respiratory medicine -- neonatology; Infants -- Diseases -- Periodicals; Newborn infants -- Diseases -- Periodicals; Fetus -- Diseases -- Periodicals; 618.920105
• DOI: 10.1136/archdischild-2021-322402
• Languages: English
• ISSNs: 1359-2998

Abstract

Abstract : Objective: To evaluate trends in respiratory care practices and bronchopulmonary dysplasia (BPD) among very preterm infants born in Spain between 2010 and 2019. Study design: This was a retrospective cohort study of data obtained from a national population-based database (SEN1500 network). Changes in respiratory care and BPD-free survival of infants with gestational age (GA) of 23 0 –31 6 weeks and <1500 g were assessed over two 5-year periods. Temporal trends were examined by joinpoint and Poisson regression models and expressed as the annual per cent change and adjusted relative risk (RR) for the change per year. Results: A total of 17 952 infants were included. In the second period, infants were less frequently intubated in the delivery room and during neonatal intensive care unit stay. This corresponded with an increase in use of non-invasive ventilation techniques. There were no significant differences between the periods in BPD-free survival or survival without moderate-to-severe BPD. After adjusting for covariates, the RR for the change per year was significant for the following variables: never intubated (RR 1.03, 95% CI 1.02 to 1.04); intubation in the delivery room (RR 0.98, 95% CI 0.97 to 0.99); use of nasal intermittent positive pressure ventilation (RR 1.08, 95% CI 1.05 to 1.11); and BPD-free survival (only in the group with the lowest GA; RR 0.98, 95% CI 0.97 to 0.99). Conclusion: Our findings reveal significant changes in respiratory care practices between 2009 and 2019. Despite an increase in use of non-invasive respiratory strategies, BPD-free survival did not improve and even worsened in the group with the lowest GA (23 0 –25 6 ). Abstract : National survey of changes in respiratory outcomes of VLBW infants over 2 periods, showing that outcome did not improve despite an increase in the use of non-invasive ventilation.