Distribution of Aspergillus Species and Prevalence of Azole Resistance in Respiratory Samples From Swiss Tertiary Care Hospitals. (18th December 2021)

• Record Type: Journal Article
• Authors: Ragozzino, Silvio; Goldenberger, Daniel; Wright, Patrick R; Zimmerli, Stefan; Mühlethaler, Konrad; Neofytos, Dionysios; Riat, Arnaud; Boggian, Katia; Nolte, Oliver; Conen, Anna; Fankhauser, Hans; Schreiber, Peter W; Zbinden, Reinhard; Lamoth, Frederic; Khanna, Nina
• Is Part Of: Open forum infectious diseases. Volume 9:Number 2(2022)
• Publication Date: 2021-12-18
• Subjects: Aspergillus fumigatus -- azole resistance -- cyp51A gene -- non-fumigatus Aspergillus spp -- TR34/L98H mutation; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofab638
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Among 400 Aspergillus species from respiratory samples in Switzerland, Aspergillus fumigatus was the most frequent species. Non- fumigatus Aspergillus spp were more prevalent among solid organ transplant recipients and after azole exposure. Azole resistance was detected in 4 A fumigatus isolates, 3 of them with the "environmental" mutation TR34 /L98H in the cyp51A gene.