A genetic association study of the IGF-1 gene and radiological osteoarthritis in a population-based cohort study (the Rotterdam study). Issue 6 (1st June 1998)

• Record Type: Journal Article
• Authors: Meulenbelt, I; Bijkerk, C; Miedema, H S; Breedveld, F C; Hofman, A; Valkenburg, H A; Pols, H A P; Slagboom, P E; van Duijn, C M
• Is Part Of: Annals of the rheumatic diseases. Volume 57:Issue 6(1998)
• Page Start: 371
• Page End: 374
• Publication Date: 1998-06-01
• Subjects: osteoarthritis -- genetics -- IGF-1; Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/ard.57.6.371
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : OBJECTIVE: A genetic association study was performed to investigate whether radiographical osteoarthritis (ROA) was associated with specific genotypes of the insulin-like growth factor I (IGF-1) gene. METHODS: Subjects aged 55–65 years were selected from a population-based study of which ROA at the knee, hip, spine, and hand was assessed. Genotypes were determined of a polymorphism in the promoter region of the IGF-1 gene. RESULTS: The IGF-1 locus was significantly associated with the presence of ROA (overall adjusted OR for heterozygous subjects = 1.9, 95% CI 1.2, 3.1 and for homozygous subjects 3.6, 95% CI 0.8, 16.2). CONCLUSION: These results suggest that variation at the IGF-1 locus is associated with ROA development and may play a part in ROA pathogenesis. To confirm these findings replication in another population-based sample is needed.