Vitamin K dietary intake is associated with cognitive function in an older adult Mediterranean population. (18th February 2022)

• Record Type: Journal Article
• Authors: Camacho-Barcia, Lucía; García-Gavilán, Jesús; Martínez-González, Miguel Ángel; Fernández-Aranda, Fernando; Galié, Serena; Corella, Dolores; Cuenca-Royo, Aida; Romaguera, Dora; Vioque, Jesús; Alonso-Gómez, Ángel M; Wärnberg, Julia; Martínez, J Alfredo; Serra-Majem, Luís; Estruch, Ramón; Bernal-López, M Rosa; Lapetra, José; Pintó, Xavier; Tur, Josep A; Garcia-Rios, Antonio; Bueno-Cavanillas, Aurora; Delgado-Rodríguez, Miguel; Matía-Martín, Pilar; Daimiel, Lidia; Martín-Sánchez, Vicente; Vidal, Josep; Vázquez, Clotilde; Ros, Emilio; Canela, Miguel Ruiz; Sorlí, Jose V; de la Torre, Rafael; Konieczna, Jadwiga; Oncina-Cánovas, Alejandro; Tojal-Sierra, Lucas; Pérez-López, Jessica; Abete, Itziar; Sánchez-Villegas, Almudena; Casas, Rosa; Muñoz-Garach, Araceli; Santos-Lozano, José Manuel; Bouzas, Cristina; Razquin, Cristina; Martínez-Lacruz, Raúl; Castañer, Olga; Yañez, Aina M; Valls-Enguix, Rafael; Belló-Mora, Maria Concepción; Basterra-Gortari, Javier; Basora, Josep; Salas-Salvadó, Jordi; Bulló, Mònica;
• Is Part Of: Age and ageing. Volume 51:Number 2(2022)
• Publication Date: 2022-02-18
• Subjects: Vitamin K -- phylloquinone -- cognitive impairment -- cognitive-neuropsychological tests -- older people; Aging -- Periodicals; Geriatrics -- Periodicals; 618.97
• DOI: 10.1093/ageing/afab246
• Languages: English
• ISSNs: 0002-0729

Abstract

Abstract: Background: In the last years, evidence that dietary vitamin K could have a role in the cognitive domain has increased. However, data from large trials are limited. The objective of this study was to assess the association of 2 year changes in the dietary intake of vitamin K with cognitive function measured through neuropsychological performance tests. Methods: In 5, 533 participants of the multicentre PREDIMED-Plus study (48.1% women, age 65.1 ± 4.9 years with overweight/obesity and metabolic syndrome), we assessed the adjusted odds ratios of cognitive function decline according to 2 year changes in vitamin K intake. Participants answered a battery of cognitive function tests and Food Frequency Questionnaires (FFQs) in order to estimate the vitamin K dietary intake. Results: After adjusting for potential cofounders, the highest tertile of change of dietary vitamin K intake (median [IQR]; 194.4 μg/d [120.9, 373.1]) was inversely associated with a Mini-Mental State Examination (MMSE) score ≤24 (OR [95% CI]; 0.53 [0.35, 0.79] P for trend = 0.002) compared with a decrease in the intake of vitamin K (median [IQR]; −97.8 μg/d [−292.8, −51.5]). A significant positive association between changes in dietary vitamin K intake and the semantic verbal fluency test scores (OR [95% CI]; 0.69 [0.51, 0.94] P for trend = 0.019) was found. Conclusions: An increase of the intake of dietary vitamin K was associated with better cognitive function scores, independently of recognised risk factors for cognitive decline, in an older adult Mediterranean population with high cardiovascular risk.