High throughput engineering and use of multi-fiber composite matrices for controlled active release. (December 2018)

• Record Type: Journal Article
• Authors: Wang, Li; Zhang, Chunchen; Wang, Hui-Min David; Ahmad, Zeeshan; Li, Jing-Song; Chang, Ming-Wei
• Is Part Of: Materials today communications. Volume 17(2018)
• Page Start: 53
• Page End: 59
• Publication Date: 2018-12
• Subjects: Centrifugal electrospinning -- Composite fibers -- Alignment -- Regulation -- Drug release; Materials science -- Periodicals; 620.11
• DOI: 10.1016/j.mtcomm.2018.08.011
• Languages: English
• ISSNs: 2352-4928

Abstract

Graphical abstract: Highlights: A tri-compartment centrifugal electrospinning system (TCCES) is demonstrated. High yielding fibrous membranes possessing increased alignment are formed in a single step. Highly aligned multi-fiber component membranes display variable mechanical and contact angle properties. Regulation of drug release from composite membranes is achieved based on inclusion of fiber type. Abstract: A tri-compartment centrifugal electrospinning system (TCCES) was designed and used to fabricate multiple fiber membranes (from individual polyvinyl pyrrolidone (PVP), thermoplastic polyurethane (TPU) and poly-methyl methacrylate (PMMA) fibers). Controlled engineering of membrane composition presents opportunities to control mechanical and water contact angle characteristics. Furthermore, control on drug release rate is achieved based on active hosting fiber type contributing towards the overall membrane. The current system enables a high degree of alignment, production rate and variations to composition, indicating clear potential in biomedical fields requiring the use of encapsulated or embedded drug in membrane materials.