Near-infrared nanoparticles based on aza-BDP for photodynamic and photothermal therapy. (January 2019)

• Record Type: Journal Article
• Authors: Liu, Yang; Song, Nan; Li, Zhensheng; Chen, Li; Xie, Zhigang
• Is Part Of: Dyes and pigments. Volume 160(2019)
• Page Start: 71
• Page End: 78
• Publication Date: 2019-01
• Subjects: Iodo-substituents aza-BDP -- NIR absorption -- Photodynamic therapy -- Photothermal therapy; Dyes and dyeing -- Periodicals; Pigments -- Periodicals; 667.2
• DOI: 10.1016/j.dyepig.2018.07.034
• Languages: English
• ISSNs: 0143-7208

Abstract

Abstract: A novel phototherapeutic agent IABDP which possessed the near infrared absorbing was synthesized and characterized. The IABDP can self-assemble into ∼200 nm nanoparticles (IABDP NPs ) with high stability by reprecipitation method. Under the low power light irradiation, it exhibits the excellent photodynamic therapy (PDT), while increasing the irradiated power, it exhibits significant photothermal therapy (PTT). Moreover, the particles can generate severe damage to HeLa and HepG2 cells and obvious inhibition effect to the tumor via synergistic PDT/PTT treatments. Graphical abstract: Image 1 Highlights: A novel NIR absorption photosensitizer IABDP has been obtained by facile synthetic procedure. The molecule based on PEGylation aza-BDP could self-assemble into nanoparticles with high stability. The introduction of iodine atoms significantly generated the photodynamic and photothermal effect. The aza-BDP nanoparticles can effectively inhibit cancer cells as well as tumors.