Autism and Cancer Share Risk Genes, Pathways, and Drug Targets. Issue 3 (March 2016)

• Record Type: Journal Article
• Authors: Crawley, Jacqueline N.; Heyer, Wolf-Dietrich; LaSalle, Janine M.
• Is Part Of: Trends in genetics. Volume 32:Issue 3(2016)
• Page Start: 139
• Page End: 146
• Publication Date: 2016-03
• Subjects: autism -- cancer -- gene -- signaling pathway -- chromatin remodeling -- DNA repair; Genetics -- Periodicals; 576.5
• DOI: 10.1016/j.tig.2016.01.001
• Languages: English
• ISSNs: 0168-9525

Abstract

Abstract : Autism is a neurodevelopmental disorder, diagnosed behaviorally by social and communication deficits, repetitive behaviors, and restricted interests. Recent genome-wide exome sequencing has revealed extensive overlap in risk genes for autism and for cancer. Understanding the genetic commonalities of autism(s) and cancer(s), with a focus on mechanistic pathways, could lead to repurposed therapeutics.