Biochemomechanical modeling of vascular collapse in growing tumors. (December 2018)
- Record Type:
- Journal Article
- Title:
- Biochemomechanical modeling of vascular collapse in growing tumors. (December 2018)
- Main Title:
- Biochemomechanical modeling of vascular collapse in growing tumors
- Authors:
- Xue, Shi-Lei
Yin, Si-Fan
Li, Bo
Feng, Xi-Qiao - Abstract:
- Highlights: Poroelastic chemomechanical theory for analyzing vascular collapse in solid tumors. Effect of biochemmechanical coupling mechanism and fluid transport on vessel buckling. Biochemomechanical finite element method for buckling and postbuckling analysis. Abstract: The collapse of blood vessels are widely observed in solid tumors, but the mechanisms underpinning this abnormal behavior remain unclear. In this paper, we investigate the stability of blood vessels embedded in a growing solid tumor by using a chemomechanical poroelastic theory. Linear stability analysis is first made to give the critical condition of vascular buckling. Thereby, pattern diagrams are provided to predict the collapsed shape of a blood vessel from the mechanical and geometric parameters of the system. Due to the mechano-chemo-biological coupling effect in tumors which involve both fluid transport and tissue growth, the buckling of blood vessels exhibits distinctly different features from such previously reported tubular tissues as airways and esophagi. We show that interstitial fluid pressure tends to drive blood vessels to buckle with a lower buckling mode, while perivascular cell proliferation favors a higher mode. Furthermore, a nonlinear biochemomechanical finite element method is formulated to track the morphological evolution of blood vessels during postbuckling. It is found that the blood vessels with the second mode of buckling may readily evolve into a crack-like shape. This methodHighlights: Poroelastic chemomechanical theory for analyzing vascular collapse in solid tumors. Effect of biochemmechanical coupling mechanism and fluid transport on vessel buckling. Biochemomechanical finite element method for buckling and postbuckling analysis. Abstract: The collapse of blood vessels are widely observed in solid tumors, but the mechanisms underpinning this abnormal behavior remain unclear. In this paper, we investigate the stability of blood vessels embedded in a growing solid tumor by using a chemomechanical poroelastic theory. Linear stability analysis is first made to give the critical condition of vascular buckling. Thereby, pattern diagrams are provided to predict the collapsed shape of a blood vessel from the mechanical and geometric parameters of the system. Due to the mechano-chemo-biological coupling effect in tumors which involve both fluid transport and tissue growth, the buckling of blood vessels exhibits distinctly different features from such previously reported tubular tissues as airways and esophagi. We show that interstitial fluid pressure tends to drive blood vessels to buckle with a lower buckling mode, while perivascular cell proliferation favors a higher mode. Furthermore, a nonlinear biochemomechanical finite element method is formulated to track the morphological evolution of blood vessels during postbuckling. It is found that the blood vessels with the second mode of buckling may readily evolve into a crack-like shape. This method can reproduce the essential features of vascular collapse observed in in vivo tumors and provide clues for vascular normalization and stress alleviation in cancer treatments. Graphical abstract: Image, graphical abstract … (more)
- Is Part Of:
- Journal of the mechanics and physics of solids. Volume 121(2018)
- Journal:
- Journal of the mechanics and physics of solids
- Issue:
- Volume 121(2018)
- Issue Display:
- Volume 121, Issue 2018 (2018)
- Year:
- 2018
- Volume:
- 121
- Issue:
- 2018
- Issue Sort Value:
- 2018-0121-2018-0000
- Page Start:
- 463
- Page End:
- 479
- Publication Date:
- 2018-12
- Subjects:
- Solid tumor -- Blood vessel -- Tissue growth -- Poroelasticity -- Buckling -- Mechano-chemo-biological coupling
Mechanics, Applied -- Periodicals
Solids -- Periodicals
Mechanics -- Periodicals
Mécanique appliquée -- Périodiques
Solides -- Périodiques
Mechanics, Applied
Solids
Periodicals
531.05 - Journal URLs:
- http://www.sciencedirect.com/science/journal/00225096 ↗
http://www.elsevier.com/journals ↗ - DOI:
- 10.1016/j.jmps.2018.08.009 ↗
- Languages:
- English
- ISSNs:
- 0022-5096
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 5016.000000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 20964.xml