Electrospun fibrous membranes of poly (lactic-co-glycolic acid) with β-tricalcium phosphate for guided bone regeneration application. (June 2020)

• Record Type: Journal Article
• Authors: Castro, Vanessa Oliveira; Fredel, Márcio Celso; Aragones, Águedo; de Oliveira Barra, Guilherme Mariz; Cesca, Karina; Merlini, Claudia
• Is Part Of: Polymer testing. Volume 86(2020)
• Publication Date: 2020-06
• Subjects: Guided bone regeneration -- Electrospinning -- Membrane -- Poly (lactic-co-glycolic acid) and β-tricalcium phosphate; Polymers -- Testing -- Periodicals; Polymères -- Tests -- Périodiques; 620.1920287
• DOI: 10.1016/j.polymertesting.2020.106489
• Languages: English
• ISSNs: 0142-9418

Abstract

Abstract: Guided bone regeneration (GBR) have been proved great success for the treatment of bone defects in oral implantology. Bone defects are reconstructed by the use of a barrier membrane which prevents the invasion of soft tissue and create a space for guiding new bone growth into the bone defect. To develop GBR membranes with higher bioactivity, poly (lactic-co-glycolic acid) (PLGA) fibrous membranes containing β-tricalcium phosphate (β-TCP) were fabricated via electrospinning. The presence of 5 wt% and 10 wt% of β-TCP in the fibers improved mechanical properties. In vitro biocompatibility results have shown that all membranes are non-cytotoxic and the presence of β-TCP increased cell adhesion and proliferation. Furthermore, cell viability results demonstrated that the presence of 5 wt% β-TCP is advantageous for osteoblast proliferation. Therefore, the results suggest that PLGA with 5 wt% β-TCP fibrous membranes meet the requirement of morphological, physical, mechanical and bioactive properties for an effective GBR membrane. Graphical abstract: Image 1 Highlights: Electrospun fibrous membranes with optimal pore size avoid fibroblasts infiltration. Porosity allows osteoblast migration and attachment, providing a good interlayer adhesion. β-TCP increases mechanical properties and bioactivity of PLGA/β-TCP membranes. Adequate quantity of β-TCP improves osteoblast proliferation and bone regeneration.