Neurobehavioral assessment of rats exposed to pristine polystyrene nanoplastics upon oral exposure. (February 2018)

• Record Type: Journal Article
• Authors: Rafiee, Mohammad; Dargahi, Leila; Eslami, Akbar; Beirami, Elmira; Jahangiri-rad, Mahsa; Sabour, Siamak; Amereh, Fatemeh
• Is Part Of: Chemosphere. Volume 193(2018)
• Page Start: 745
• Page End: 753
• Publication Date: 2018-02
• Subjects: Polystyrene nanoplastics -- Neurobehavioral effects -- Wistar rat -- Oral administration; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2017.11.076
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: The increasing use of plastics has raised concerns about pollution of freshwater by these polymeric materials. Knowledge about their potential effects on environmental and public health is limited. Recent publications have suggested that the degradation of plastics will result in the release of nano-sized plastic particles to the environment. Therefore, it is of utmost importance to gain knowledge about whether and how nanoplastics affect living organisms. The present study aimed to analyse potential neurobehavioral effects of polystyrene nanoparticles (PS-NPs) after long-term exposure on rat. Potential effects of PS-NPs were investigated using four test dosages (1, 3, 6, and 10 mg PS-NPs/kg of body weight/day) administrated orally with adult Wistar male rats for five weeks. Neurobehavioral tests were chosen to assess a variety of behavioral domains. Particle diameters in test suspensions were determined through dynamic light scattering and showed an average hydrodynamic diameter of approximately 38.92 nm. No statistically significant behavioral effects were observed in all tests performed (p > 0.05). In the elevated plus maze, PS-NPs-exposed rats showed greater number of entries into open arms compared to controls. Also, PS-NPs had no significant influence on body weight of animals. Taking into account the subtle and transient nature of neurobehavioral consequences, however, these results underline the possibility of even pristine plastic nanoparticles to induce behavioral alteration in the rest of the food web, including for marine biota and humans. Indeed even though studied neurobehavioral effects in our study was not statistically significant, the observed subtle effects may be clinically considerable. Highlights: The impacts of virgin nanoplastics on a suite of neurobehavioral responses in adult Wistar rats were investigated. Exposure to plastic nanoparticles resulted in no measurable neurobehavioral consequences over the duration of the study. Subtle and transient nature of effects highlight the potential of nanoplastics to have direct/indirect effects on human.