Antimicrobial activity of a conjugated polymer with cationic backbone. (January 2019)

• Record Type: Journal Article
• Authors: Xu, Qingling; He, Ping; Wang, Jianwu; Chen, Hui; Lv, Fengting; Liu, Libing; Wang, Shu; Yoon, Juyoung
• Is Part Of: Dyes and pigments. Volume 160(2019)
• Page Start: 519
• Page End: 523
• Publication Date: 2019-01
• Subjects: Conjugated polymer -- Antimicrobial -- Cationic backbone -- Imidazolium; Dyes and dyeing -- Periodicals; Pigments -- Periodicals; 667.2
• DOI: 10.1016/j.dyepig.2018.08.049
• Languages: English
• ISSNs: 0143-7208

Abstract

Abstract: Owing to the misuse of antibiotics and slow development of new drugs, antibiotic-resistant pathogens have become a serious threat to human health. With the aim of developing new antimicrobial agents, we designed and synthesized a new conjugated polymer (PFPhim ), which possesses an imidazolium containing backbone. The cationic backbone enables it to strongly interact with bacterial membrane leading to an antimicrobial ability that is more potent than that of a conjugated polymer containing a neutral backbone. PFPhim also displays strong photodynamic antimicrobial activity. Graphical abstract: Image 1 Highlights: A conjugated polymer possessing imidazolium in the backbone was synthesized. The polymer shows good an bacterial ability over Ampr E. Coli in darkness. The polymer also displays strong photodynamic antimicrobial activity.