Change in cardio-protective medication and health-related quality of life after diagnosis of screen-detected diabetes: Results from the ADDITION-Cambridge cohort. Issue 1 (July 2015)

• Record Type: Journal Article
• Authors: Black, J.A.; Long, G.H.; Sharp, S.J.; Kuznetsov, L.; Boothby, C.E.; Griffin, S.J.; Simmons, R.K.
• Is Part Of: Diabetes research and clinical practice. Volume 109:Issue 1(2015)
• Page Start: 170
• Page End: 177
• Publication Date: 2015-07
• Subjects: Diabetes -- HRQoL -- Medication; Diabetes -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462
• DOI: 10.1016/j.diabres.2015.04.013
• Languages: English
• ISSNs: 0168-8227

Abstract

Highlights: We examined individuals with screen-detected diabetes over five years. Two cardio-protective agents were prescribed at diagnosis, 3 at one year and 4 at five years. Increases in cardio-protective medication did not impact negatively on HRQoL. Abstract: Aims: Establishing a balance between the benefits and harms of treatment is important among individuals with screen-detected diabetes, for whom the burden of treatment might be higher than the burden of the disease. We described the association between cardio-protective medication and health-related quality of life (HRQoL) among individuals with screen-detected diabetes. Methods: 867 participants with screen-detected diabetes underwent clinical measurements at diagnosis, one and five years. General HRQoL (EQ5D) was measured at baseline, one- and five-years, and diabetes-specific HRQoL (ADDQoL-AWI) and health status (SF-36) at one and five years. Multivariable linear regression was used to quantify the association between change in HRQoL and change in cardio-protective medication. Results: The median (IQR) number of prescribed cardio-protective agents was 2 (1 to 3) at diagnosis, 3 (2 to 4) at one year and 4 (3 to 5) at five years. Change in cardio-protective medication was not associated with change in HRQoL from diagnosis to one year. From one year to five years, change in cardio-protective agents was not associated with change in the SF-36 mental health score. One additional agent was associated with an increase in the SF-36 physical health score (2.1; 95%CI 0.4, 3.8) and an increase in the EQ-5D (0.05; 95%CI 0.02, 0.08). Conversely, one additional agent was associated with a decrease in the ADDQoL-AWI (−0.32; 95%CI −0.51, −0.13), compared to no change. Conclusions: We found little evidence that increases in the number of cardio-protective medications impacted negatively on HRQoL among individuals with screen-detected diabetes over five years.