Association of age-of-onset groups with GWAS significant schizophrenia and bipolar disorder loci in Romanian bipolar I patients. Issue 3 (30th December 2015)

• Record Type: Journal Article
• Authors: Grigoroiu-Serbanescu, Maria; Diaconu, Carmen C.; Heilmann-Heimbach, Stefanie; Neagu, Ana Iulia; Becker, Tim
• Is Part Of: Psychiatry research. Voume 230:Issue 3(2015)
• Page Start: 964
• Page End: 967
• Publication Date: 2015-12-30
• Subjects: EGFR -- MMP16 -- CNNM2 genes; Psychiatry -- Periodicals; Psychiatry -- periodicals; Psychiatrie -- Périodiques; 616.89
• DOI: 10.1016/j.psychres.2015.11.008
• Languages: English
• ISSNs: 0165-1781

Abstract

Abstract: We investigated the influence of the age-of-onset (AO) on the association of 45 loci conferring risk for bipolar disorder (BP) and schizophrenia with BP-type-I in a Romanian sample (461 patients, 436 controls). The AO-analysis implicated the EGFR gene, as well as loci in other genes, in the AO variation of BP-type-I and revealed for the first time the link between BP-type-I and risk variants considered specific to schizophrenia (polymorphisms in MMP16 / RIPK2 and CNNM2 genes). Highlights: Age of onset of bipolar disorder (BP) implicates EGFR, MAD1L1, TRANK1, AS3MT genes. MMP16 and CNNM2 genes, previously linked to schizophrenia, were involved in BP too. Early-onset BP (≤24 years) was associated with MMP16 gene. Association of EGFR, AS3MT, NT5C2, CNNM2, NCAN genes with late-onset BP (≥25 years).