The NF‐κB transcription factor c‐Rel controls host defense against Citrobacter rodentium. Issue 2 (25th November 2019)

• Record Type: Journal Article
• Authors: Luu, Maik; Romero, Rossana; Bazant, Jasmin; Abass, Elfadil; Hartmann, Sabrina; Leister, Hanna; Fischer, Florence; Mahdavi, Rouzbeh; Plaza‐Sirvent, Carlos; Schmitz, Ingo; Steinhoff, Ulrich; Visekruna, Alexander
• Is Part Of: European journal of immunology. Volume 50:Issue 2(2020)
• Page Start: 292
• Page End: 294
• Publication Date: 2019-11-25
• Subjects: Citrobacter rodentium -- c‐Rel -- CD4+ T cells -- B cells -- NF‐κB; Immunology -- Periodicals; 616.079
• DOI: 10.1002/eji.201948314
• Languages: English
• ISSNs: 0014-2980

Abstract

Abstract : Mice lacking CD4 + T cells or B cells are highly susceptible to Citrobacter rodentium infection. In this study, we show that the activity of the transcription factor c‐Rel in lymphocytes is crucial for clearance of C. rodentium . Mice deficient for c‐Rel fail to generate protective antibodies and to eradicate the pathogen.