Acute lymphoblastic leukaemia (ALL) things come to those who wait: 60 years of progress in the treatment of adult ALL. (15th November 2020)

• Record Type: Journal Article
• Authors: Fielding, Adele K.; Goldstone, Anthony H.
• Is Part Of: British journal of haematology. Volume 191:Number 4(2020)
• Page Start: 558
• Page End: 561
• Publication Date: 2020-11-15
• Subjects: adult -- acute lymphoblastic leukaemia -- TRIALS; Hematology -- Periodicals; Blood -- Diseases -- Periodicals; 616.15
• DOI: 10.1111/bjh.17166
• Languages: English
• ISSNs: 0007-1048

Abstract

Summary: The UK has made a well‐recognised contribution to the international effort to understand and treat acute lymphoblastic leukaemia (ALL) in adults. Work done in the UK by numerous personnel over many years has been instrumental in developing novel risk stratifications, evaluating treatment strategies for adult patients with de novo and relapsed disease and in making novel scientific contributions. The UK has championed and achieved very high levels of recruitment to clinical trials and, in particular, is known for success in large, investigator‐initiated randomised controlled trials. This historical review charts the progress of clinical research in adult ALL from its inception to the present day.