A Glycosylated Covalent Organic Framework Equipped with BODIPY and CaCO3 for Synergistic Tumor Therapy. Issue 41 (17th August 2020)

• Record Type: Journal Article
• Authors: Guan, Qun; Zhou, Le‐Le; Lv, Fan‐Hong; Li, Wen‐Yan; Li, Yan‐An; Dong, Yu‐Bin
• Is Part Of: Angewandte Chemie international edition. Volume 59:Issue 41(2020)
• Page Start: 18042
• Page End: 18047
• Publication Date: 2020-08-17
• Subjects: calcium overload -- cancer -- covalent organic frameworks -- photodynamic therapy -- reticular chemistry; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.202008055
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Ca 2+, a ubiquitous but nuanced modulator of cellular physiology, is meticulously controlled intracellularly. However, intracellular Ca 2+ regulation, such as mitochondrial Ca 2+ buffering capacity, can be disrupted by 1 O2 . Thus, the intracellular Ca 2+ overload, which is recognized as one of the important cell pro‐death factors, can be logically achieved by the synergism of 1 O2 with exogenous Ca 2+ delivery. Reported herein is a nanoscale covalent organic framework (NCOF)‐based nanoagent, namely CaCO3 @COF‐BODIPY‐2I@GAG (4 ), which is embedded with CaCO3 nanoparticle (NP) and surface‐decorated with BODIPY‐2I as photosensitizer (PS) and glycosaminoglycan (GAG) targeting agent for CD44 receptors on digestive tract tumor cells. Under illumination, the light‐triggered 1 O2 not only kills the tumor cells directly, but also leads to their mitochondrial dysfunction and Ca 2+ overload. An enhanced antitumor efficiency is achieved via photodynamic therapy (PDT) and Ca 2+ overload synergistic therapy. Abstract : A multifunctional COF‐based nanoagent, which is equipped with BODIPY‐2I photosensitizer, CaCO3 nanoparticle, and glycosaminoglycan (GAG) targeting agent, can be a highly efficient and selective antitumor nanomedicine for colon tumor via photodynamic therapy (PDT) and Ca 2+ overload synergistic therapy.